The Lilly TB Drug Discovery Initiative

Collaboration Opportunities

The Lilly TB Drug Discovery Initiative is a not-for-profit public-private partnership with a mission to accelerate early-stage drug discovery for the treatment of tuberculosis. You are invited to submit for review information on compounds of interest or target-based screening assays that may be appropriate for this effort.

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Welcome

Recognizing that Mycobacterium tuberculosis (Mtb) knows no borders, the National Institute of Allergy and Infectious Disease (NIAID) has developed a global tuberculosis (TB) R&D agenda to fight this illness. The resurgence in TB rates and the growing incidence of multi-drug resistant TB (MDR-TB) and extensively drug resistant TB (XDR-TB) has sparked a renewed commitment by government agencies, nongovernmental organizations (NGOs), Public Private Partnerships (PPPs) and the private sector to begin developing new drugs to fight TB. The general consensus among infectious disease experts is that the entire world will be at risk for TB epidemics in the future and new, more effective drugs are desperately needed to facilitate treatment and control of tuberculosis.

A key component in advancing new interventions for TB is the creation of productive partnerships between biotechnology and pharmaceutical companies and NIAID. To achieve this objective, the NIAID has established a consortium of drug discovery and development resources to:

  • stimulate biotechnology company investment in TB drug development and
  • help reduce risks and costs associated with the development process

NIAID supports these efforts through its own laboratory research as well as through extramural support from universities and other research organizations. All groups collaborate with industry to integrate drug development expertise in the programs.

As part of NIAIDs TB Drug Development Program, RTI International is actively facilitating partnerships between biotechnology companies, research labs, foundations, and international organizations to cooperatively develop, test, and introduce new TB therapies. Find out how.

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Latest News

Apr 9, 2010- - New WHO Report Estimates 440,000 MDR-TB Cases Worldwide In 2008
There were an estimated 440,000 cases of multidrug-resistant tuberculosis (MDR-TB) ...


Apr 9, 2010- - Lanka to eradicate TB by 2025
Tuberculosis (TB) will be eradicated from Sri Lanka by 2025, twenty five years ahead ...


Apr 9, 2010- - New way to fight TB is proposed
Johns Hopkins University scientists say they have identified a class of compounds ...


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Upcoming Events

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Literature

Apr 9, 2010Drug-Resistant Tuberculosis Acrobat PDF File
Although the incidence of tuberculosis (TB) in Germany is now declining, the world ...


Apr 9, 2010Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates Acrobat PDF File
We describe in this work the synthesis of nine new fluoroquinolone derivatives based ...


Apr 9, 2010Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824  Acrobat PDF File
The PA-824 analogues used in this study displayed similar activities against Mycobacterium ...