Welcome

Recognizing that Mycobacterium tuberculosis (Mtb) knows no borders, the National Institute of Allergy and Infectious Disease (NIAID) has developed a global tuberculosis (TB) R&D agenda to fight this illness. The resurgence in TB rates and the growing incidence of multi-drug resistant TB (MDR-TB) and extremely drug resistant TB (XDR-TB) has sparked a renewed commitment by government agencies, nongovernmental organizations (NGOs), Public Private Partnerships (PPPs) and the private sector to begin developing new drugs to fight TB. The general consensus among infectious disease experts is that the entire world will be at risk for TB epidemics in the future and new, more effective drugs are desperately needed to facilitate treatment and control of tuberculosis.

A key component in advancing new interventions for TB is the creation of productive partnerships between biotechnology and pharmaceutical companies and NIAID. To achieve this objective, the NIAID has established a consortium of drug discovery and development resources to:

  • stimulate biotechnology company investment in TB drug development and
  • help reduce risks and costs associated with the development process

NIAID supports these efforts through its own laboratory research as well as through extramural support from universities and other research organizations. All groups collaborate with industry to integrate drug development expertise in the programs.

As part of NIAIDs TB Drug Development Program, RTI International is actively facilitating partnerships between biotechnology companies, research labs, foundations, and international organizations to cooperatively develop, test, and introduce new TB therapies. Find out how.

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Latest News

Aug 15, 2008- - Outcomes of nevirapine- and efavirenz-based antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy
Rifampicin-based antitubercular therapy reduces the plasma concentrations of nevirapine ...


Aug 15, 2008- - Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes
A series of hydrazone and 3-nitrovinyl analogs of indole-3-carboxaldehydes and related ...


Aug 15, 2008- - Extensively drug-resistant tuberculosis: current challenges and threats
Worldwide prevalence of XDR-TB is estimated to be c. 6.6 in all the studied countries ...


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Upcoming Events

Aug 26, 2008 – TB in Corrections: Contact Investigation and Discharge Planning Course
This training course is designed to enhance communication and collaboration between local health departments and corrections personnel to improve cont...


Aug 26, 2008 – Tuberculosis Clinical Intensive
This three-day course is designed for physicians and other licensed medical professionals who diagnose and treat TB.


Sep 1, 2008 – International Course in Budget Planning and Project Management for TB Control
This course will be a two-week intensive program specifically designed for financial managers and senior managers working at the national level in TB ...


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Literature

Aug 15, 2008Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives Acrobat PDF File
A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have ...


Aug 15, 2008Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure-Activity Relationships of the Nucleobase Domain of 5'-O-[N-(Salicyl)sulfamoyl]adenosine  Acrobat PDF File
5'- O-[ N-(salicyl)sulfamoyl]adenosine (Sal-AMS) is a prototype for a new class ...


Aug 15, 2008Active site of mycobacterial dUTPase: Structural characteristics and a built-in sensor  Acrobat PDF File
dUTPases are essential to eliminate dUTP for DNA integrity and provide dUMP for ...