The Lilly TB Drug Discovery Initiative

Collaboration Opportunities

The Lilly TB Drug Discovery Initiative is a not-for-profit public-private partnership with a mission to accelerate early-stage drug discovery for the treatment of tuberculosis. You are invited to submit for review information on compounds of interest or target-based screening assays that may be appropriate for this effort.

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Welcome

Recognizing that Mycobacterium tuberculosis (Mtb) knows no borders, the National Institute of Allergy and Infectious Disease (NIAID) has developed a global tuberculosis (TB) R&D agenda to fight this illness. The resurgence in TB rates and the growing incidence of multi-drug resistant TB (MDR-TB) and extensively drug resistant TB (XDR-TB) has sparked a renewed commitment by government agencies, nongovernmental organizations (NGOs), Public Private Partnerships (PPPs) and the private sector to begin developing new drugs to fight TB. The general consensus among infectious disease experts is that the entire world will be at risk for TB epidemics in the future and new, more effective drugs are desperately needed to facilitate treatment and control of tuberculosis.

A key component in advancing new interventions for TB is the creation of productive partnerships between biotechnology and pharmaceutical companies and NIAID. To achieve this objective, the NIAID has established a consortium of drug discovery and development resources to:

  • stimulate biotechnology company investment in TB drug development and
  • help reduce risks and costs associated with the development process

NIAID supports these efforts through its own laboratory research as well as through extramural support from universities and other research organizations. All groups collaborate with industry to integrate drug development expertise in the programs.

As part of NIAIDs TB Drug Development Program, RTI International is actively facilitating partnerships between biotechnology companies, research labs, foundations, and international organizations to cooperatively develop, test, and introduce new TB therapies. Find out how.

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Latest News

Jun 30, 2009- - TB Alliance Announces Four Drug Discovery Collaborations
The TB Alliance announced at the Global Health Council Conference that four drug ...


Jun 30, 2009- - Scientists find promising new TB target
Scientists from the University of Wisconsin-Madison studying how sugar units form ...


Jun 30, 2009- - Lancet Infectious Diseases Examines Spread Of XDR-TB
The journal Lancet Infectious Diseases examines the worldwide spread of extensively ...


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Upcoming Events

Jul 14, 2009 – TB Nurse Case Management
This two-and-a-half day training targets public health TB nurses and program managers who are actively engaged in the case management, identification,...


Jul 16, 2009 – The TB Cohort Review Process
This is a one-and-a-half-day course for selected teams of TB controllers, program managers, clinicians, and epidemiologists – especially from cities, ...


Jul 21, 2009 – Tuberculosis Program Manager's Intensive
This course is for nurses, physicians, and other health professionals working as TB program managers.


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Literature

Jun 30, 2009Synthesis, in vitro antitubercular activity and 3D-QSAR study 0f 1,4-dihydropyridines Acrobat PDF File
This article is a report of the synthesis of 97 various symmetrical, unsymmetrical, ...


Jun 30, 2009Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: An essential step towards target-based drug design Acrobat PDF File
Mtb shikimate dehydrogenase (MtbSD) catalyzes the forth reaction in the shikimate ...


Jun 30, 2009Unorthodox Approach to the Development of a New Antituberculosis Therapy Acrobat PDF File
The development of TMC207.