The Lilly TB Drug Discovery Initiative

Collaboration Opportunities

The Lilly TB Drug Discovery Initiative is a not-for-profit public-private partnership with a mission to accelerate early-stage drug discovery for the treatment of tuberculosis. You are invited to submit for review information on compounds of interest or target-based screening assays that may be appropriate for this effort.

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Welcome

Recognizing that Mycobacterium tuberculosis (Mtb) knows no borders, the National Institute of Allergy and Infectious Disease (NIAID) has developed a global tuberculosis (TB) R&D agenda to fight this illness. The resurgence in TB rates and the growing incidence of multi-drug resistant TB (MDR-TB) and extensively drug resistant TB (XDR-TB) has sparked a renewed commitment by government agencies, nongovernmental organizations (NGOs), Public Private Partnerships (PPPs) and the private sector to begin developing new drugs to fight TB. The general consensus among infectious disease experts is that the entire world will be at risk for TB epidemics in the future and new, more effective drugs are desperately needed to facilitate treatment and control of tuberculosis.

A key component in advancing new interventions for TB is the creation of productive partnerships between biotechnology and pharmaceutical companies and NIAID. To achieve this objective, the NIAID has established a consortium of drug discovery and development resources to:

  • stimulate biotechnology company investment in TB drug development and
  • help reduce risks and costs associated with the development process

NIAID supports these efforts through its own laboratory research as well as through extramural support from universities and other research organizations. All groups collaborate with industry to integrate drug development expertise in the programs.

As part of NIAIDs TB Drug Development Program, RTI International is actively facilitating partnerships between biotechnology companies, research labs, foundations, and international organizations to cooperatively develop, test, and introduce new TB therapies. Find out how.

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Latest News

Feb 19, 2010- - Clinical Trial Proves New Vaccine Effective In Preventing TB In African Patients With HIV Infection
Investigators from Dartmouth Medical School (DMS) have reported results of a clinical ...


Feb 19, 2010- - Atlantic Examines Drug-Resistant TB Control Worldwide
"The resurgence of tuberculosis is not limited to South Africa. India and China ...


Feb 19, 2010- - Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in the West. Europe and United States: Epidemiology, Surveillance, and Control
Adherence to internationally agreed standards of care and control practices is imperative ...


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Upcoming Events

Mar 16, 2010 – TB Case Management and Contact Investigation Intensive
This course is intended for physicians, nurses, and other licensed medical care providers who manage patients with TB or who are at risk for TB.


Apr 12, 2010 – TB Infection Control: Training Course for Managers at National and Sub-National Levels
This course is addressed to TB and HIV/AIDS managers needing to ensure implementation of adequate infection control measures at the national and subna...


Jun 1, 2010 – The South African TB Conference 2010
Attendees will come together to review the evidence and to debate and develop innovative approaches to fight the TB epidemic in the era of HIV.


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Literature

Feb 19, 2010Outcomes after Chemotherapy with WHO Category II Regimen in a Population with High Prevalence of Drug Resistant Tuberculosis Acrobat PDF File
Standard short course chemotherapy is recommended by the World Health Organization ...


Feb 19, 2010Synthesis and Structure-activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Acrobat PDF File
Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed ...


Feb 19, 2010Synthesis and Structure-Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-[4-(trifluoromethoxy)benzyl]oxy-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824) Acrobat PDF File
A series of biphenyl analogues of the new tuberculosis drug PA-824 was prepared, ...