News


The Medical News
Sequella, Inc. announced that it received a $694,000 grant supplement as part of the American Recovery and Reinvestment Act (ARRA) of 2009 which will be used to further the development of their lead antitubercular compound, SQ109.

Science Daily
Researchers at Iowa State University have identified an enzyme that helps make tuberculosis resistant to a human's natural defense system. Researchers have also found a method to possibly neutralize that enzyme, which may someday lead to a cure for tuberculosis.

RedOrbit
A new study published in PLoS ONE found that patients with cavitary pulmonary tuberculosis receiving anti-TB medications supplemented with nebulized interferon-gamma have fewer bacilli in the lungs and less inflammation, thereby reducing the transmissibility of tuberculosis in the early phase of treatment.

Medical News Today
Timothy A. Cross, a Florida State University researcher, has received a major research grant from the National Institutes of Health (NIH) to screen small molecules that could be potential drug targets in the fight against tuberculosis.

Mail Guardian
TB prevalence has increased almost threefold in the last 10 years. A recent report by Statistics South Africa found that for every 100 deaths in 2006, 13 were from TB. This made the sickness the number one cause of death in South Africa.

Washington Post
Preliminary state statistics for Russia show the rate of TB infection growing from 83.2 cases per 100,000 people in 2007 to 85.2 in 100,000 last year.

Gang Lin, et al
Researchers identified "two compounds that can destroy a defense mechanism in the tuberculosis bacterium that allows it to remain dormant in infected cells.

Aidsmap
TMC207 shortened treatment time and cleared five times more patients of multidrug-resistant TB compared to the background regimen alone.

Kristen Holland Shear
The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

Henry J. Kaiser Family Foundation
In Russia, preliminary state statistics show the rate of drug-resistant TB infections growing from 83.2 cases per 100,000 people in 2007 to 85.2 in 100,000 last year.

United Press International
Common use of fluoroquinolones has been linked to an antibiotic-resistant tuberculosis, U.S. researchers said.

AsianWeek Staff Report
The Lilly MDR-TB Partnership, founded in 2003, is a public-private affiliation of 18 global organizations that formed to eradicate MDR-TB in this lifetime.

Ivanhoe
New forms of tuberculosis could swell the proportion of drug-resistant cases globally, a new study has found. Although TB incidence is falling in many regions, the emergence of antibiotic resistance could see virtually untreatable strains of the disease become widespread.

Koul S, Somayajulu A, Advani MJ, Reddy H.
Researchers show evidence that trifluoperazine interferes with the activation of NAD-kinase and PDE activities.

Mark Tanaka
The relative "reproductive fitness" of resistant and drug-sensitive Mtb strains are comparable.

The Medical News
The latest drug regimens, vaccines and diagnostic tools under development to combat tuberculosis could have a potentially large impact on the disease once they become available.

Reuters
Johnson and Johnson announced recently that it has joined with the nonprofit Global Alliance for TB Drug Development to speed commercialization of its experimental TB drug, TMC207.

Johns Hopkins Medicine
Johns Hopkins researchers have developed a novel way to monitor in real time the behavior of the TB bacterium in mouse lungs noninvasively pinpointing the exact location of Mycobacterium tuberculosis.

ScienceDaily
Researchers at the Technische Universität München have now cast light on a metabolic step that appears in many aggressive microorganisms like tuberculosis or malaria pathogens and that may provide a promising target for a new class of antibiotics.

ScienceDaily
A team of Harvard scientists has taken an important first step toward the development of new treatments to help people with HIV battle Mycobacterium tuberculosis (TB) infection.
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